ChemiClean effectively removes stains from red, black, blue-green, and methane (bubble) producing cyanobacteria in marine aquariums. For best results remove or turn off protein skimmers, UV sterilizer, and Ozonizer when using Chemiclean. Always place an airstone in your aquarium while you are using ChemiClean. You will see results within 48 hours of placing the treatment into your water as it oxidizes the trapped organic sludge and sediments. It is reef safe and can treat up to 300 gal of water.